About

I am a physician–scientist working at the intersection of medical imaging, machine learning, and clinical decision support. My work focuses on developing AI systems that are interpretable, uncertainty-aware, and aligned with real clinical workflows—spanning 3D imaging analysis, multimodal modeling, and structured information extraction.

I currently work in academic medical research, collaborating with radiologists, data scientists, and clinicians to design end-to-end pipelines that translate technical advances into meaningful clinical value. This includes building imaging segmentation and feature extraction pipelines, developing large-language-model systems for structured reporting, and incorporating causal reasoning and predictive modeling to support evidence-based decision-making.

Beyond imaging AI, my interests include longitudinal risk modeling, population-level analytics, digital health tools, and the integration of equity principles into clinical informatics. I am committed to translational impact—bridging technology, medicine, and global health to make advanced AI capabilities accessible across diverse healthcare settings.

Research Philosophy: AI in healthcare should be clinically grounded, transparent, and designed for real-world use. I strive to build systems that complement clinician expertise, enhance decision-making, and improve patient care in a safe and responsible way.

Education

M.S. in Biomedical Informatics & Data Science

Johns Hopkins School of Medicine, USA

M.D.

Universitas Sriwijaya, Indonesia

Research Focus

Advancing real-world clinical impact through imaging analytics, longitudinal modeling, and trustworthy AI systems.

Pancreatic Imaging & Early Cancer Detection
Advancing early detection of pancreatic cancer by building multi-structure segmentation models for pancreas, cyst, and duct anatomy using nnU-Net pipelines. Current work focuses on radiomics feature extraction and uncertainty-aware classification of IPMN subtypes (low-grade, high-grade, invasive) to reduce unnecessary surgeries and support personalized surveillance strategies.
RadiomicsnnU-NetCT Imaging
400+ IPMN casesdataset
Pancreas / Cyst / Ductstructures
Clinical LLM Systems & Structured Reporting
Building robust clinical NLP systems using large language models for structured information extraction from radiology reports. This includes prompt engineering, fine-tuning domain-specific LLMs, multi-agent pipelines for cross-verification, and strict output validation via Pydantic schemas. Additional work includes tool-assisted generation, hallucination mitigation, batched report processing, and automated error recovery for scalable synoptic reporting.
Fine-TuningPrompt EngineeringLLM PipelinesStructured Reporting
400+ reportsDataset
Multi-agent + Pydanticmethods
Longitudinal Risk & Treatment Response Modeling
Leading large-scale longitudinal modeling of lipid-lowering therapy patterns using 200M+ laboratory measurements. Work includes real-world evaluation of LDL estimation methods (Martin, Sampson, Friedewald), quantifying initiation and intensification rates after LDL changes, and measuring population-level treatment responsiveness.
Real-World EvidenceLongitudinal ModelingCardiometabolic Risk
100K+ patients, 200M+ labsdataset
Clinical Decision Support & Uncertainty Modeling
Developing interpretable, clinically aligned AI models that integrate imaging features, clinical metadata, and causal reasoning. This includes conformal prediction for calibrated uncertainty, SHAP-based interpretability, and resection-versus-surveillance risk stratification frameworks to support real-world decision-making.
XAICausal InferenceUncertainty Modeling

Selected Publications

Full publication list available on Google Scholar · PubMed · ORCID

Editorial

Automating Visual Abstracts in Radiology with Vision-Language Models: Practical Insights

Chu LC, Syailendra EA

Radiology2025

DOI: 10.1148/radiol.252731

Editorial

Balancing Model Generalization With Local Performance: Insights From AI in Prostate Cancer Classification

Syailendra EA, Rahmatullah Z, Lopez-Ramirez F, Chu LC

Can Assoc Radiol J2025

DOI: 10.1177/08465371251377467

Review

Early detection of pancreatic cancer on computed tomography: advancements with deep learning

Lopez-Ramirez F, Syailendra EA, Tixier F, Kawamoto S, Fishman EK, Chu LC

Radiol Adv2025

DOI: 10.1093/radadv/umaf028

Article

Ensuring Reproducibility and Deploying Models with the Image2Radiomics Framework: An Evaluation of Image Processing on PanNET Model Performance

Tixier F, Lopez-Ramirez F, Syailendra EA, Blanco A, Javed AA, Chu LC, Kawamoto S, Fishman EK

Cancers (Basel)2025

DOI: 10.3390/cancers17152552

Contact

Email
msyaile1@jhu.edu

Lab inquiries: felix.project@jh.edu

Collaboration Inquiry
Affiliation

Post-doctoral Research Fellow
Felix Lab
Johns Hopkins Medicine
Russel H. Morgan Department of Radiology

Office Location

JHOC 3251
601 N Caroline St
Baltimore, MD 21287

Office Hours

Mon-Fri 9:00 AM-5:00 PM EST